79-year-old woman with Osteoporosis, CVI and Rheumatoid arthritis (incl cortisone therapy) presents a wound with infected necrosis on the left, lower leg after trauma. The wound duration is 3 weeks. Systemic antibiotic treatment started 8 days after initial wound assessment and for a period of 12 days. The systemic antibiotic treatment was followed by removal of necrosis via debridement, local antimicrobial therapy and exudate management. Initial dressing change interval was every 2 days.